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Gentzon Hall, MD/Ph.D.

 

Biochemistry 2007

Area of Doctoral Study: Biochemistry
Undergraduate Institute: University of Maryland Baltimore County

Research Advisor:  Dr. Terry Rogers, UMB

Current Position: Medical Instructor, Departmentof Medicine, Member of Duke University Molecular Physiology Institute

Description of Research

Heart disease is the leading cause of death in the United States, claiming nearly 1 million lives annually.  Myocardial production of proinflammatory cytokines, such as tumor Necrosis Factor- µ,  (TNF-µ), is now regarded as a significant contributor to various cardiac pathologies.  While several suggest that members of the Nuclear Factor family of transcription factors are essential regulators of myocardial TNF-µ gene expression, recent developments in our understanding of the modulation of NF- kB activity through post-transitional modification of NF -kB subunits suggest that the current view of NF-kB dependent cytokine expression in heart is incomplete Therefore, the goal of this study was to examine how phosphorylation of the NF -kB p65 subunit regulates TNF-µ production in cultured neonatal ventricular cardiomyocytes.