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Mirelis Santos Cancel

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Chemistry and Biochemistry

Area of Doctoral Study: Chemistry

Undergraduate Institute: University of Puerto Rico, Mayaguez

Graduate Institute: University of Puerto Rico, Mayaguez

Research Advisor: Ryan White, Ph.D.

Description of Research

My research projects is focused on the development of an integrated nanoscale-and-nanostructured translatable electrochemical aptamer-based (E-AB) sensor with high spatial and temporal resolution to study ATP released from gliotransmission events. This experiment includes the use of a 3-D collagen scaffold with a dual purpose: mimic brain conditions and be a bioreactor for the seed, growth and differentiation of astrocyte cells. In long terms this platform will be used as a quantitative tool to study neurological diseases such as Alzheimer’s disease.

An adjunct project involves the use of 3-D collagen scaffold as biocompatible protector to enable long-term function of E-AB sensors in complex biological samples such as serum and whole blood. This experiment includes the use of a novel electrode design patterned using photolithography.